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Laboratory researchers use a pipette and cell culture plate in a chemical safety testing environment, with a laboratory mouse visible in a cage and a screen highlighting EPA’s goal of ending mammalian animal testing by 2035. The image represents the shift toward human-relevant, non-animal testing methods and innovative approaches to chemical safety assessment.

Rethinking Chemical Safety: EPA Advances Alternatives to Animal Testing

Explore how the landmark methylene chloride ruling could reshape TSCA chemical compliance, EPA risk assessments, workplace protections, and business obligations.
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A judge’s gavel rests in front of the U.S. Supreme Court building, illustrating the Fifth Circuit’s landmark decision vacating the EPA’s methylene chloride rule and requiring risk evaluations to consider specific conditions of use, personal protective equipment, real-world workplace conditions, economic impacts, and regulatory alternatives.

Beyond Methylene Chloride: What a Landmark TSCA Ruling Means for Chemical Compliance

Explore how the landmark methylene chloride ruling could reshape TSCA chemical compliance, EPA risk assessments, workplace protections, and business obligations.
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A conceptual illustration showing TSCA (US) and REACH (EU) regulatory frameworks balanced against one another, emphasizing chemical compliance, supply chain communication, risk management, and global market access considerations for businesses operating across multiple jurisdictions.

US TSCA vs. EU REACH: What Global Businesses Need to Know About Chemical Compliance

Compare US TSCA and EU REACH regulations, understand their key differences, and learn how businesses can build effective global chemical compliance strategies.
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US EPA Releases August 2025 TSCA Inventory Update

On August 14, 2025, the EPA released its latest TSCA Inventory update. The list now includes 86,862 chemicals, with updates to CBI status, activity, and regulatory flags.
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EPA TSCA UPDATES

EPA Provides Technical Support for Submission of New Chemical Data Under TSCA  

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TSCA Risk Management Program: A State of the Union

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US TSCA Update – Section 5

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Recent Developments in the US EPA’s Toxic Substances Control Act (TSCA) New and Existing Chemical Programs 

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US EPA is planning a monumental 2024 for TSCA

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EPA Finalise the Next 20 High Priority Chemicals Under TSCA

In December 2019, the EPA finalized the next 20 high priority (but not necessarily high risk) chemicals which are set to undergo a risk evaluation under TSCA. The risk evaluation process will commence with a public comment period and by June 2020, the EPA will finalize scoping documents for the 20 chemicals that will be...
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Draft Risk Evaluation for Methylene Chloride

Methylene chloride is currently being evaluated under TSCA and a draft risk evaluation was released in October 2019, which evaluated 72 conditions of use for the chemical. Methylene chloride is a volatile chemical that is used as a solvent for various purposes in industrial, commercial, and consumer settings. It is mainly used for paint removal,...
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Draft risk evaluation for N-methylpyrrolidone (NMP)

A draft risk evaluation for N-methylpyrrolidone (NMP) was published in November 2019 and evaluated 30 potential uses of NMP. The EPA evaluation characterized unreasonable risks associated with acute and chronic inhalation and dermal exposure to NMP. NMP is used in adhesives and adhesive removers, sealants, paints and removers, and degreasers. The document focuses on worker...
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